Biokinetic Analysis of Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in Severe Traumatic Brain Injury Patient Biofluids
نویسندگان
چکیده
منابع مشابه
Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction
Ubiquitin C-terminal hydrolase L1 (UCH-L1) is an extremely abundant protein in the brain where, remarkably, it is estimated to make up 1-5% of total neuronal protein. Although it comprises only 223 amino acids it has one of the most complicated 3D knotted structures yet discovered. Beyond its expression in neurons UCH-L1 has only very limited expression in other healthy tissues but it is highly...
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Abstract: Parkinson's disease (PD) and Alzheimer's disease (AD), two of the most common neurodegenerative diseases, are caused by both genetic and environmental factors. Mammalian neuronal cells abundantly express a deubiquitinating (DUB) enzyme, Ubiquitin Carboxy-terminal hydrolase L1 (UCH-L1), which is involved in the pathogenesis of both of these neurodegenerative diseases. This DUB is selec...
متن کاملUbiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats.
Ubiquitin C-terminal hydrolase-L1 (UCH-L1), also called neuronal-specific protein gene product 9.5, is a highly abundant protein in the neuronal cell body and has been identified as a possible biomarker on the basis of a recent proteomic study. In this study, we examined whether UCH-L1 was significantly elevated in cerebrospinal fluid (CSF) following controlled cortical impact (CCI) and middle ...
متن کاملUbiquitin C-Terminal Hydrolase L1 in Tumorigenesis
Ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1, aka PGP9.5) is an abundant, neuronal deubiquitinating enzyme that has also been suggested to possess E3 ubiquitin-protein ligase activity and/or stabilize ubiquitin monomers in vivo. Recent evidence implicates dysregulation of UCH-L1 in the pathogenesis and progression of human cancers. Although typically only expressed in neurons, high levels o...
متن کاملExpression of ubiquitin C-terminal hydrolase L1 (UCH-L1) and its prognostic significance in esophageal squamous cell carcinoma
Objective: To explore the expression of ubiquitin carboxyl-terminal esterase L1 (UCH-L1) in the esophageal squamous cell carcinoma (ESCC) as well as its clinical significance. Methods: 215 cases of ESCC were evaluated by tissue microarray and immunohistochemistry for UCH-L1 expression and its clinical significance and prognostic value was investigated. Results: The positive rate of UCH-L1 was 4...
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ژورنال
عنوان ژورنال: Journal of Neurotrauma
سال: 2011
ISSN: 0897-7151,1557-9042
DOI: 10.1089/neu.2010.1564